Foundayo at Curely

Treatment Details

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Foundayo Doses
Side Effects of Foundayo
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What is Foundayo?
Foundayo is the brand name for orforglipron, a once-daily oral GLP-1 receptor agonist developed by Eli Lilly for weight management.
Unlike injectable GLP-1 weight loss medications, Foundayo comes as a tablet. It is taken once a day, making it an option for people who would prefer an oral weight loss treatment rather than an injection.
Foundayo is prescribed alongside a reduced-calorie diet and increased physical activity for adults with obesity, or adults who are overweight and have at least one weight-related medical condition.
How Does Foundayo Work?
Foundayo contains orforglipron, a GLP-1 receptor agonist.
GLP-1 is a naturally occurring hormone involved in regulating appetite and blood sugar. By activating GLP-1 receptors, Foundayo can help:
- Reduce appetite and hunger
- Increase feelings of fullness after eating
- Reduce overall calorie intake
- Support blood sugar regulation
- Promote sustained weight loss
These effects can make it easier to follow a reduced-calorie diet and develop healthier eating habits over the long term.
Foundayo differs from Mounjaro (tirzepatide). Mounjaro acts on both GIP and GLP-1 receptors, whereas Foundayo acts on the GLP-1 receptor.
How Effective is Foundayo for Weight Loss?
Clinical trials have shown that Foundayo can produce significant weight loss when used alongside a reduced-calorie diet and increased physical activity.
In the 72-week ATTAIN-1 clinical trial involving more than 3,100 adults with obesity or overweight and at least one weight-related health condition, participants taking Foundayo achieved greater average weight loss than those receiving placebo.
Weight loss increased according to the treatment dose. At 72 weeks, average body weight reductions included approximately:
- 7.4% with Foundayo 5.5 mg
- 8.3% with Foundayo 9 mg
- 11.1% with Foundayo 17.2 mg
Individual results vary. Weight loss medication works best when combined with sustainable changes to diet, physical activity and other lifestyle factors.
What are the Benefits of Foundayo?
As an oral GLP-1 weight loss treatment, Foundayo may offer several benefits:
- Clinically proven weight loss
- Once-daily oral tablet
- No injections or needles required
- Can be taken with or without food
- Helps reduce appetite
- Helps you feel fuller for longer
- Supports long-term weight management
- Multiple strengths allow treatment to be gradually adjusted
- Can support improvements in metabolic health alongside weight loss
Foundayo should be used as part of a wider weight-management programme incorporating a reduced-calorie diet and increased physical activity.
Who Can Take Foundayo for Weight Loss?
Foundayo is a prescription-only medicine and must be prescribed following an appropriate clinical assessment.
It is licensed for weight management in adults with obesity, or adults who are overweight and have at least one weight-related health condition.
Your eligibility will be assessed by a Curely prescribing clinician. This assessment considers your BMI, medical history, current medication, previous weight loss treatment and overall health.
Not everyone will be suitable for Foundayo. Your clinician will determine whether it is an appropriate and safe treatment for you.
How to Take Foundayo
Foundayo is taken once daily by mouth.
Take Foundayo exactly as prescribed by your clinician.
- Take one Foundayo tablet once each day.
- It can be taken with or without food.
- Swallow the tablet whole.
- Do not break, crush or chew the tablet.
- Do not take more than one tablet in the same day.
Unlike some oral GLP-1 treatments, Foundayo does not require you to take the tablet on an empty stomach, which can make it easier to incorporate into your daily routine.
Foundayo is available in several tablet strengths:
0.8 mg
2.5 mg
5.5 mg
9 mg
14.5 mg
17.2 mg
Treatment normally begins with 0.8 mg once daily.
The dose is then gradually increased to help your body adjust to the medication and reduce the likelihood of gastrointestinal side effects.
The usual dose escalation is:
0.8 mg once daily
Starting dose.
2.5 mg once daily
After at least 30 days on 0.8 mg.
5.5 mg once daily
After at least 30 days on 2.5 mg.
Depending on your response and how well you tolerate treatment, your clinician may then recommend increasing to:
9 mg → 14.5 mg → 17.2 mg
Each increase should normally occur only after at least 30 days on the current dose.
What Happens if I Miss a Foundayo Dose?
If you forget to take Foundayo, take the missed tablet as soon as you remember.
Do not take two Foundayo tablets on the same day to make up for a missed dose.
If you have missed Foundayo for 7 days or longer, speak to your prescribing clinician before restarting treatment. Your dose may need to be reviewed before you resume taking the medicine.
Like all medicines, Foundayo can cause side effects, although not everyone will experience them.
The most commonly reported Foundayo side effects affect the digestive system. They are often more noticeable when starting treatment or following an increase in dose.
Common Foundayo Side Effects
Common side effects can include:
Nausea
Constipation
Diarrhoea
Vomiting
Indigestion
Abdominal pain or discomfort
Bloating
Acid reflux or heartburn
Burping
Flatulence
Headache
Fatigue
Hair loss
In clinical trials, nausea, constipation, diarrhoea and vomiting were among the most frequently reported adverse effects.
Gradually increasing the Foundayo dose helps your body adjust to treatment and can reduce the likelihood or severity of gastrointestinal side effects.
It is important to stay adequately hydrated, particularly if you experience vomiting or diarrhoea.
Serious Side Effects
Although less common, Foundayo can cause more serious side effects.
These can include:
Pancreatitis:
Seek urgent medical advice if you develop severe and persistent abdominal pain, particularly if the pain spreads towards your back, with or without nausea or vomiting.
Severe gastrointestinal problems:
Speak to a healthcare professional if you experience severe or persistent stomach problems.
Dehydration and kidney problems:
Persistent vomiting or diarrhoea can cause dehydration and potentially affect kidney function. Drink adequate fluids and seek medical advice if symptoms do not improve.
Low blood sugar:
The risk of hypoglycaemia can be higher when Foundayo is used alongside certain diabetes medicines, including insulin or sulfonylureas.
Serious allergic reactions:
Seek immediate medical attention if you experience swelling of your face, lips, tongue or throat, difficulty breathing or swallowing, severe rash, fainting or other symptoms of a serious allergic reaction.
If you develop severe, persistent or worrying symptoms while taking Foundayo, seek medical advice.
Is Foundayo the Same as Mounjaro?
No. Foundayo and Mounjaro are both developed by Eli Lilly and influence hormones involved in appetite and weight management, but they are different medicines.
Foundayo contains orforglipron and is a GLP-1 receptor agonist taken as a once-daily tablet.
Mounjaro contains tirzepatide and activates both GIP and GLP-1 receptors. It is administered as a once-weekly injection.
Both medicines can support weight loss, but their active ingredients, mechanisms and dosing schedules are different.
Your prescribing clinician can help determine which treatment is most appropriate for you.
Foundayo vs Wegovy
Foundayo and Wegovy both act on the GLP-1 receptor and can be prescribed for weight management, but they contain different active ingredients.
Foundayo contains orforglipron, while Wegovy contains semaglutide.
One of the main differences is how Foundayo is taken. Foundayo is an oral tablet taken once each day and can be taken with or without food.
The most suitable treatment depends on factors including your medical history, previous treatment, weight-management goals, side effects and personal preferences.
Can I Switch from Mounjaro or Wegovy to Foundayo?
It may be possible for some patients to switch from another GLP-1 weight loss treatment to Foundayo.
However, you should not switch treatments yourself or take Foundayo at the same time as another GLP-1 receptor agonist.
If you are currently taking Mounjaro, Wegovy or another weight loss medication, tell your Curely clinician during your consultation. They will assess your current dose, treatment history, side effects and the timing of your most recent dose before recommending an appropriate treatment plan.
Can Foundayo Be Used for Weight Maintenance?
Foundayo is designed not only to help reduce excess body weight but also to support long-term weight management.
Reaching your target weight does not necessarily mean that treatment should be stopped immediately. Obesity is a long-term condition, and stopping effective weight management treatment can result in appetite returning and weight regain for some people.
At Curely, your clinician can review your progress and determine whether continued treatment, a change in dose or another weight-maintenance strategy is most appropriate.
The aim is to find the lowest effective treatment approach that helps you maintain a healthy, sustainable weight while minimising side effects.
Who Should Not Take Foundayo?
Foundayo is not suitable for everyone.
Before starting treatment, tell your clinician about your full medical history and any medicines you currently take.
Foundayo should not be used alongside another GLP-1 receptor agonist.

Can I Take Foundayo with Other Weight Loss Medicines?
Foundayo should not be taken together with another GLP-1 receptor agonist, including other GLP-1-based weight loss treatments.
Always tell your prescribing clinician about prescription medicines, over-the-counter medicines, vitamins and supplements you currently use.
Foundayo can affect the absorption or action of some medicines, so your clinician needs an accurate medication history before prescribing treatment.
Buy Foundayo Online in the UK
Foundayo is a prescription-only medicine in the UK and should only be supplied following an appropriate clinical assessment by a qualified prescriber.
Through Curely's online weight management service, eligible patients can complete an online consultation which is reviewed by a UK prescribing clinician.
Your clinician will assess your BMI, health, current medication and treatment history before deciding whether Foundayo is suitable for you.
If approved, your Foundayo prescription will be dispensed by Curely's UK-registered pharmacy and delivered discreetly to your chosen address.
Never purchase Foundayo or other prescription weight loss medicines from an unregulated website or seller.
References

Frequently asked questions

Is Foundayo available in the UK?
Foundayo (orforglipron) is a prescription-only weight loss medicine. Availability through Curely will depend on UK supply and stock availability. You can join the Curely Foundayo priority list to receive updates when Foundayo becomes available to order.
How much will Foundayo cost in the UK?
The price of Foundayo will depend on the tablet strength prescribed and UK supply arrangements. Curely aims to offer competitive pricing across its weight loss treatments. Join our Foundayo priority list to receive launch, availability and pricing updates.
When will Foundayo be available to buy from Curely?
Curely plans to make Foundayo available to eligible patients subject to stock availability and clinical prescribing requirements. Join the Foundayo priority list and we will let you know when Foundayo is available through Curely.
Is Foundayo a tablet or an injection?
Foundayo is a once-daily weight loss tablet, not an injection. It contains orforglipron, an oral GLP-1 receptor agonist developed by Eli Lilly.
Unlike injectable GLP-1 treatments such as Mounjaro and Wegovy, Foundayo is swallowed as a tablet once a day. This may make it an attractive option for people looking for a GLP-1 weight loss treatment without injections or needles.
How quickly does Foundayo start working?
Foundayo begins acting on GLP-1 receptors after starting treatment, but weight loss is expected to occur gradually over time. Treatment begins at a lower dose before being increased gradually to help improve tolerability.
How quickly you notice changes in appetite or weight will vary from person to person. Foundayo should be used alongside a reduced-calorie diet and increased physical activity for long-term weight management.
How much weight can you lose with Foundayo?
Weight loss with Foundayo varies between individuals and depends on factors including your dose, starting weight, diet, physical activity and response to treatment.
In the 72-week ATTAIN-1 clinical trial, participants taking the 17.2 mg dose achieved an average body weight reduction of approximately 11.1%. Lower doses also produced clinically meaningful weight loss.
These figures are averages from clinical trials and do not guarantee how much weight an individual patient will lose.
Do you need a prescription for Foundayo in the UK?
Yes. Foundayo is a prescription-only medicine and cannot be legally supplied in the UK without an appropriate prescription.
When available through Curely, you will need to complete a clinical assessment. A qualified prescribing clinician will review your BMI, medical history, current medicines and other relevant information before determining whether Foundayo is suitable for you.
Can I take Foundayo with food?
Yes. Foundayo can be taken with or without food, giving you flexibility over when you take your daily tablet.
Take Foundayo once a day as directed by your prescriber and swallow the tablet whole. You should not crush, chew or split the tablet.
Does Foundayo need to be kept in the fridge?
Foundayo is an oral tablet rather than an injectable weight loss pen. Follow the storage instructions supplied with your Foundayo medication and keep it in its original packaging.
Always check the patient information leaflet supplied with your medicine for the manufacturer's current storage instructions.
Is Foundayo better than Mounjaro for weight loss?
Foundayo and Mounjaro are different weight loss medicines, and one treatment will not necessarily be better for every patient.
Foundayo contains orforglipron and is a once-daily GLP-1 tablet. Mounjaro contains tirzepatide, targets both GIP and GLP-1 receptors and is administered as a once-weekly injection.
Mounjaro has demonstrated greater average weight loss in its clinical trials than has currently been reported for Foundayo, but Foundayo has the significant advantage of being an oral tablet. For people who do not want injections, a daily GLP-1 pill may be preferable.
The best weight loss treatment for you will depend on your medical history, treatment goals, previous medication, response to treatment and personal preferences. A prescribing clinician can help determine the most appropriate option.