Patients who review Differin in the UK report that it is usually well-tolerated with positive ratings. But as with all topical treatments, there is a possibility of skin sensitivity or allergy.

We recommend performing a small patch test before beginning your full treatment regimen to make sure you can use Differin safely.

If you do experience side effects from Differin cream/gel, they can include:

• Dryness
• Itching
• Redness
• Burning
• Stinging
• Tingling
• Skin peeling
• Mild rash

Important Safety Guidance

• Consult Information: Always read the enclosed Patient Information Leaflet for safety information and a full list of potential side effects before use.
• Report Reactions: If you experience any extreme discomfort or adverse effects, let us know or contact your GP.

How to use Differin

Follow these simple steps:

• Clean & Prepare: Gently wash the affected area with a mild cleanser.
• Apply Differin Thinly: Apply a small amount of Differin Cream or Gel to your fingertips. Dot and spread a thin layer over the entire affected area and rub it in lightly.
• Wait For Absorption: You may use cosmetics and moisturisers with Differin cream/gel. However, wait until it’s fully absorbed into the skin before applying anything else.
• Use: Apply only to the affected areas once a day, in the evening.
• Cautions: Differin has a drying effect on the skin, so avoid using any toiletries containing alcohol or other skin-drying ingredients.

What to Expect

When you use differin correctly, it can produce effects similar to mild sunburn, including itching and redness. The affected area will also feel warm. This is normal at the start of the treatment and should subside.

Acne treatment requires patience and consistency. Use Differin continuously for up to three months, depending on response, to get the best results. You may experience the ‘Differin purge,’ where you’ll see more breakouts in the first two to four weeks. Expect improvement after a few weeks. 

PIL: https://www.medicines.org.uk/emc/files/pil.921.pdf

Benefits of Differin

✓ Stops Acne at the Source: Goes deep into pores to clear existing breakouts and prevent new ones from forming.
✓ Calms & Soothes: More stable and less irritating than older retinoids.
✓ Transforms Skin Texture: Promotes cell renewal to smooth roughness and improve skin clarity and softness.
✓ Fades Post-Acne Marks: Accelerates natural exfoliation to help reduce the appearance of stubborn dark spots left after breakouts.
✓ Balances & Refines: Regulates excess oil and keeps pores clear for a more balanced complexion with less noticeable pores.
✓ Anti-Aging Support: With continued use, Differin supports collagen production and maintains skin’s youthful look.

Who Can Use Differin?

• Ages 12+: Approved for teenagers and adults in the UK.
• People with Oily Skin: Good at managing excess oil.
• People with Mild to Moderate Acne: Effective for whiteheads, blackheads, and inflammatory pimples.
• People with Dark Spots: Great choice for those looking to fade post-acne marks (hyperpigmentation).

Who Should NOT Use Differin:

• Pregnant Women: Do not use Differin if you are pregnant or planning to become pregnant due to potential risks to the fetus.
• Children Under 12: Studies have not confirmed safety for children under 12.
• People with Extremely Sensitive Skin: Differin may cause irritation or flares if you have conditions like eczema, rosacea, or seborrheic dermatitis.
• Damaged Skin: Never apply adapalene gel to broken skin, open wounds, or active sunburns.
• Specific Allergies: Avoid Differin if you are hypersensitive to Adapalene or any of the inactive ingredients.

Special Considerations (Proceed with Caution)

• Breastfeeding: You can use Differin while breastfeeding. However, avoid applying it to the chest/nipple area and consult your GP before use.
• Dry Skin Types: Use the cream version. Or use the gel version with a thick moisturizer to prevent peeling.
• Waxing: Do not wax any area of the skin where you apply Differin. It thins the top layer of skin and can cause skin lifting (where the wax pulls the skin with it).

Warning: If you experience any swelling of the face, difficulty breathing, or an intense rash, stop using it immediately, as these can be signs of an allergic reaction.

Ingredients

Active Ingredients

• Adapalene 0.1% (retinoid)

Inactive Ingredients

• Carbomer 940
• Edetate Disodium
• Methylparaben
• Poloxamer 182
• Propylene Glycol
• Purified water and Sodium Hydroxide
• May contain Hydrochloric Acid to adjust pH.

Getting Your Adapalene Gel UK Prescription

Skip the in-person queue. Receive your Differin gel UK treatment discreetly to your door with free, fully tracked shipping on orders over £20 from Curely. Complete our quick online consultation to start.

Safe & Secure, Guaranteed

Your well-being is Curely’s priority. Every medication we provide, including Differin, comes exclusively from regulated UK-authorized distributors to guarantee safety and the highest standard of pharmaceutical care.