Switching from Mounjaro to Wegovy: What You Need to Know

What is Wegovy?

Wegovy is a weekly injection created by Novo Nordisk, used to aid weight loss. It contains semaglutide, a GLP-1 receptor agonist that works by mimicking natural hormones in your body to help control hunger, make you feel full longer, and support eating less — all of which can lead to sustainable weight loss.

While it’s not the same as Mounjaro, which also targets the GIP receptor, Wegovy injection is still considered a strong alternative and has shown similar results in numerous studies.

Although both medications work in slightly different ways, both help reduce appetite and influence eating habits. In practice, this means people often feel full more quickly, have fewer cravings, and find it easier to adjust their eating habits in support of their weight loss goals.

Both treatments have also been shown to support meaningful weight loss, while also helping to improve blood pressure, blood sugar levels, cholesterol, and overall wellbeing.

What are the benefits of switching to Wegovy?

• Lower risk of obesity-related health issues: By losing excess weight, Wegovy users may decrease their chances of developing conditions like heart disease, high blood pressure, and sleep apnea.
• Significant weight loss: Clinical studies have shown that Wegovy can lead to impressive weight loss, often exceeding 15% of a person’s starting weight.
• Better blood sugar control: Many users experience improved blood sugar levels, which can be especially beneficial for those with type 2 diabetes.
• Improved quality of life: Weight loss with Wegovy often results in greater mobility, boosted self-esteem, and an overall enhanced sense of well-being.

Wegovy vs. Mounjaro for Weight Loss

Another popular weight loss injection is Mounjaro, and it's often compared to Wegovy. However, there are some key differences between the two.

Wegovy works as a GLP-1 agonist, meaning it mimics the natural GLP-1 hormone released after eating. This helps increase feelings of fullness, curb hunger, and reduce food intake, leading to effective weight loss. On the other hand, Mounjaro targets both GLP-1 and GIP receptors, offering a dual-action approach that can enhance its weight loss effects.

In clinical trials, those using Wegovy saw an average weight loss of around 15% over 12 months, highlighting its effectiveness for weight management on its own.

While there aren’t direct head-to-head studies comparing these two medications yet, existing research shows that both Wegovy and Mounjaro can help with weight loss. Ultimately, anyone considering these treatments should speak with their healthcare provider to find the best option for their individual health needs.

How can I switch?

At Curely, we know switching medications can feel like a big decision, but it’s more of a continuation than a reset. Our clinical team will carefully review your situation to make sure the transition from Mounjaro to Wegovy is smooth and safe. We’ll look at things like:

• Your current weight loss progress
• How long you’ve been using Mounjaro
• Any side effects you’ve had
• Your dosing history and future goals

If you’ve had a positive experience with Mounjaro, we might be able to start you on a higher dose of Wegovy. But if you’ve had issues like nausea or bloating, we’ll likely begin with a lower dose to help your body adjust more comfortably. 

Here’s a table showing potential equivalent doses for transitioning from Mounjaro (tirzepatide) to Wegovy (semaglutide). Keep in mind that the exact dosing will depend on individual factors and should always be tailored by your clinical team.

This is a general guideline, and your dose will be based on how well you’ve tolerated Mounjaro, any side effects you’ve experienced and your individual goals. It’s always important to follow the advice provided by your clinical team.

Considering switching to Wegovy

To start your switch to Wegovy, just fill out the assessment form and choose the dose you’d like. This helps us get a clear picture of your medical history and treatment so far.

Once we receive your form, our clinical team will review it to make sure the dose you picked is safe and suitable for you.

We understand that starting a new treatment or switching medications can feel overwhelming, but at Curely Pharmacy, we’re here to make the process simpler. Our experienced team is ready to answer your questions, support you through side effects, and help you understand your medication and dosing.

Whether you're continuing with Mounjaro, transitioning to Wegovy, or exploring other treatment paths, we’ll help you find what works best for you. Our focus is on providing clear, personalised care—so you feel supported, informed, and confident at every stage of your journey.

FAQs

Can I stop Mounjaro and start Wegovy at the lowest dose?
Yes, you can. Many people choose to begin Wegovy at the lowest dose (0.25 mg), especially if they had side effects with Mounjaro or want to take a gentler approach. That said, your starting dose will depend on your medical background and how you tolerated treatment previously. Our clinical team will guide you to the right starting point. 

Can I switch to Wegovy if my BMI is under 30?
Wegovy is approved for people with a BMI of 30 or higher, or 27+ if there’s a related health condition like high blood pressure, PCOS, insulin resistance, or sleep apnoea. If your BMI has dropped below 30 after using Mounjaro, you might still be eligible to switch—our team will assess if it's clinically appropriate.

Can I use Wegovy for weight maintenance?
Yes—keeping weight off is just as important as losing it. Wegovy can be a helpful option for long-term maintenance if you’ve hit your target weight or are getting close. We’ll work with you to stabilise your dose and help prevent rebound weight gain. 

How long can I stay on Wegovy?
There’s no set time limit. Long-term studies have shown Wegovy is safe to use over time, as long as it's effective for you and you’re being monitored. Like other chronic conditions, weight management often needs ongoing treatment to keep results steady and support overall health.

How long does an opened Wegovy pen last?
Once you start using a Wegovy pen, it should be stored in the fridge or at room temperature (up to 30°C) and used within 6 weeks. Always check the expiry date and follow storage guidelines.

Do I need to wait between stopping Mounjaro and starting Wegovy?
Yes, a short break is recommended. We usually advise a 3-week gap between your last Mounjaro dose and your first Wegovy injection. This gives your body time to reset and helps reduce the risk of side effects when switching medications.

Will Wegovy help me lose as much weight as Mounjaro?
Results vary from person to person, but studies suggest similar outcomes—especially with higher doses of Wegovy (like the upcoming 7.2 mg version in the UK). If Wegovy is a good fit for you, we’ll help tailor the dose to support your goals. 

Can I switch to Wegovy if I had side effects on Mounjaro?
Yes. If you experienced nausea, bloating, or other side effects on Mounjaro, we can start you on a lower dose of Wegovy to help your body adjust more comfortably. Your prescriber will recommend the best approach based on your experience.